Longitudinal Proteomic Profiling of T Cell Differentiation In Vivo Reveals Biochemical Remodeling Underlying Exhaustion
Christian Michel Beusch, Abdelhameed S. Dawood, Ahmet Ozdilek, Sarah Welbourn, Youssef M. Zohdy, Christopher M. Monaco, Alexandra S. Flegle, Ahmed Mahgoub, Sakshi Malik, Christina Niavi, Akil Akhtar, Carly J. Roman, Autumn A. Gavora, David Ezra Gordon, Mohamed S. Abdel-Hakeem
This study profiles longitudinal proteomic and phosphoproteomic changes in CD8 T cells during acute and chronic infections, identifying exhaustion-associated proteins and phosphosites with potential therapeutic relevance.
bioRxiv · May 14, 2024 · PreprintImmunology