Author

Akil Akhtar

Emory UniversityORCID 0000-0002-9069-6827Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Organism:mouse· 2 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Research Focus:host-pathogen & immune response· 1 Assay:proteomics· 1

Frequent Co-Authors

Abdelhameed S. Dawood· 1 shared Ahmed Mahgoub· 1 shared Ahmet OzdilekiD· 1 shared Alexandra S. FlegleiD· 1 shared Anish SuriiD· 1 shared Autumn A. Gavora· 1 shared Carly J. RomaniD· 1 shared Christian Michel BeuschiD· 1 shared

Activity by Year

2024-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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1 shared paperImmunology

Abdelhameed S. Dawood

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Simultaneous TCR and IL-2 agonism selectively enhances epitope-specific CD8 T cell responses during chronic viral infection

Masao Hashimoto, Mohammad Affan Khan, Akil Akhtar, Javed Naim Agrewala, Gordon James Freeman, Natasha M. Girgis, Yu Zhang, Simon Low, Steven N. Quayle, Anish Suri, Rafi Ahmed

This study shows that targeting IL-2 to antigen-specific CD8 T cells enhances their responses during chronic viral infection while sparing non-targeted populations, and combining this with PD-1 blockade further improves outcomes.

Journal of Virology · Jun 15, 2026Peer-reviewedImmunology

Longitudinal Proteomic Profiling of T Cell Differentiation In Vivo Reveals Biochemical Remodeling Underlying Exhaustion

Christian Michel Beusch, Abdelhameed S. Dawood, Ahmet Ozdilek, Sarah Welbourn, Youssef M. Zohdy, Christopher M. Monaco, Alexandra S. Flegle, Ahmed Mahgoub, Sakshi Malik, Christina Niavi, Akil Akhtar, Carly J. Roman, Autumn A. Gavora, David Ezra Gordon, Mohamed S. Abdel-Hakeem

This study profiles longitudinal proteomic and phosphoproteomic changes in CD8 T cells during acute and chronic infections, identifying exhaustion-associated proteins and phosphosites with potential therapeutic relevance.

bioRxiv · May 14, 2024 · PreprintImmunology