Heparanase, a host gene that potently restricts retrovirus transcription
Brandon Waxman, K. Salka, Uddhav Timilsina, Supawadee Umthong, Deepak Shukla, Spyridon Stavrou
This study identifies HPSE as a host factor that restricts retrovirus infection by inhibiting proviral transcription through sequestration of the SP1 transcription factor.
mBio · Feb 25, 2025Peer-reviewedMicrobiology