ALS/FTD-linked TDP-43 alterations prevent HSV-1 infection by disrupting cell-adhesion pathways
Stephanie Jackvony, Laraib Ijaz, Evelyn J. Hardin, Abulimiti Aikedan, Constance Q. Zhou, Tejabhiram Yadavalli, Minwoo Wendy Jang, Matthew Mahoney, Li Gan, Deepak Shukla, Adam L. Orr, Anna G. Orr
This study shows that TDP-43 mutations in ALS/FTD reduce HSV-1 infection by disrupting cell-adhesion pathways and impairing viral entry.
bioRxiv · Oct 2, 2026 · PreprintNeuroscience