Developmental BiologyiSciencePeer-reviewed
A human-specific, concerted repression of microcephaly genes contributes to radiation-induced growth defects in forebrain organoids
Jéssica Honorato Ribeiro, Emre Etlioglu, Jasmine Buset…·Roel Quintens
The paper shows that radiation-induced DNA damage in human forebrain organoids leads to microcephaly through a human-specific p53-E2F4 repression of microcephaly genes.