Author

Roel Quintens

Belgian Nuclear Research CentreORCID 0000-0002-4359-3403Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 1 Developmental Biology· 1 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 3 Research Focus:differential expression· 3 Approach:statistical model· 3 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Organism:human· 2 Organism:mouse· 2

Frequent Co-Authors

André Claude Mbouombouo Mfossa· 2 shared Emre EtliogluiD· 2 shared Sarah BaatoutiD· 2 shared Winnok Harald De VosiD· 2 shared A. Claeys· 1 shared Anggraeini Puspitasari-KokkoiD· 1 shared Ann Janssen· 1 shared Danny HuylebroeckiD· 1 shared

Activity by Year

2020-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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2 shared papersDevelopmental Biology

André Claude Mbouombouo Mfossa

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Author profile →

3 papers

Recent·Most cited

Heterogeneous and conserved radiation responses reveal FOXM1-dependent regulation of microcephaly genes in glioblastoma

Lou Van Eupen, Emre Etlioglu, Kevin Tabury, Keith Lloyd Ligon, Rosa Aguirre, Marleen Derweduwe, A. Claeys, Anggraeini Puspitasari-Kokko, Irina Primac, Frederik De Smet, Roel Quintens

The paper identifies FOXM1-dependent regulation of microcephaly genes in glioblastoma radiation response, showing that FOXM1 inhibition enhances radiosensitivity.

bioRxiv · Sep 2, 2026 · PreprintCancer Biology

A human-specific, concerted repression of microcephaly genes contributes to radiation-induced growth defects in forebrain organoids

Jéssica Honorato Ribeiro, Emre Etlioglu, Jasmine Buset, Ann Janssen, Hanne Puype, Lisa Berden, André Claude Mbouombouo Mfossa, Winnok Harald De Vos, Vanessa Vermeirssen, Sarah Baatout, Nicholas Rajan, Roel Quintens

The paper shows that radiation-induced DNA damage in human forebrain organoids leads to microcephaly through a human-specific p53-E2F4 repression of microcephaly genes.

iScience · Jan 20, 2025Peer-reviewedDevelopmental Biology

p53 drives premature neuronal differentiation in response to radiation-induced DNA damage during early neurogenesis

André Claude Mbouombouo Mfossa, Mieke Verslegers, Tine Verreet, Haris bin Fida, Mohamed Mysara, Wilfred F. J. van IJcken, Winnok Harald De Vos, Lieve Moons, Sarah Baatout, Mohammed Abderrafi Benotmane, Danny Huylebroeck, Roel Quintens

bioRxiv · Jun 26, 2020 · PreprintNeuroscience