A human-specific, concerted repression of microcephaly genes contributes to radiation-induced growth defects in forebrain organoids
Jéssica Honorato Ribeiro, Emre Etlioglu, Jasmine Buset, Ann Janssen, Hanne Puype, Lisa Berden, André Claude Mbouombouo Mfossa, Winnok Harald De Vos, Vanessa Vermeirssen, Sarah Baatout, Nicholas Rajan, Roel Quintens
The paper shows that radiation-induced DNA damage in human forebrain organoids leads to microcephaly through a human-specific p53-E2F4 repression of microcephaly genes.
iScience · Jan 20, 2025Peer-reviewedDevelopmental Biology