Author

Bryan C. Neumann

University of California, IrvineORCID 0000-0002-9596-1300Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:cryo-EM· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Assay:imaging· 1 Organism:mouse· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Shane GoneniD· 2 shared Abdul Samad· 1 shared Bonnie J. CuthbertiD· 1 shared Celia W. GouldingiD· 1 shared Christopher S. HayesiD· 1 shared David A. LowiD· 1 shared Diego Acosta‐AlveariD· 1 shared Fernando Garza‐SáncheziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersMicrobiology

Shane GonenORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization

Michael S. Costello, Bryan C. Neumann, Bonnie J. Cuthbert, Jana Holubová, Mia W. Raimondi, Fernando Garza‐Sánchez, Abdul Samad, Ladislav Bumba, Jacob A. Torres, Nickolas J. Holznecht, Jessica Mendoza, Ondřej Staněk, Sasiprapa Prombhul, Thomas Weimbs, Meghan A. Morrissey, , Christopher S. Hayes

This study shows that the Bordetella FhaB protein's microtubule-binding domain is delivered into host cells to promote bacterial colonization by interacting with microtubules in cilia.

Science · Feb 19, 2026Peer-reviewedMicrobiology

Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I

Bryan Neumann, Stephen McCarthy, Shane Gonen

This study determines the cryo-EM structures of human NaV1.8 with and without the peptide Protoxin-I, revealing how the peptide inhibits channel activation by displacing the VSDII S3-S4 linker.

Nature Communications · Feb 7, 2025Peer-reviewedBiophysics