Stephen McCarthy

This study determines the cryo-EM structures of human NaV1.8 with and without the peptide Protoxin-I, revealing how the peptide inhibits channel activation by displacing the VSDII S3-S4 linker.

This paper uses MD simulations, NMR, and SAXS to characterise the cis and trans proline conformations of ORF6CTR from SARS-CoV-2, showing good agreement between simulations and experiments.

This study uses AlphaFold and RosettaCM to model 18 uncharacterized delta-conotoxins, providing structural insights and implications for drug development.