Shane Gonen

Capsular Polysaccharide Safeguards a Prophage-Bacterium Symbiosis by Preventing Collateral Attack and Promoting Viral Transmission

The paper identifies capsular polysaccharides as a mechanism that stabilizes prophage-bacterium symbiosis by preventing collateral viral attack and enhancing transmission.

Bacteria deliver a microtubule-binding protein into mammalian cells to promote colonization

This study shows that the Bordetella FhaB protein's microtubule-binding domain is delivered into host cells to promote bacterial colonization by interacting with microtubules in cilia.

Phollow: Visualizing Gut Bacteriophage Transmission within Microbial Communities and Living Animals

Phollow tracks phage replication and spread in zebrafish guts with single-virion resolution, revealing rapid uptake by intestinal cells and antibiotic-induced shifts in microbial communities.

Structural basis of inhibition of human NaV1.8 by the tarantula venom peptide Protoxin-I

This study determines the cryo-EM structures of human NaV1.8 with and without the peptide Protoxin-I, revealing how the peptide inhibits channel activation by displacing the VSDII S3-S4 linker.

Enhanced Suppression of Stenotrophomonas maltophilia by a Three-Phage Cocktail: Genomic Insights and Kinetic Profiling

This paper identifies and characterizes three phages that form a cocktail effective against Stenotrophomonas maltophilia, showing enhanced bacterial suppression compared to individual phages.

Delta-Conotoxin Structure Prediction and Analysis through Large-scale Comparative and Deep Learning Modeling Approaches

This study uses AlphaFold and RosettaCM to model 18 uncharacterized delta-conotoxins, providing structural insights and implications for drug development.

Near-Atomic Cryo-EM Imaging of a Small Protein Displayed on a Designed Scaffolding System

The paper demonstrates that small proteins can be visualized at near-atomic resolution using cryo-EM when attached to a symmetric protein scaffold.