Molecular BiologybioRxivPreprint
Topologically Engineered Tetrahedral Antibody Architectures for Multispecific Therapy
Daniel J. Capon, Larisa Troitskaya, Marina E. Fomin…·Nelson L.S. Chan
This paper engineers tetrahedral antibodies with a non-planar architecture to overcome steric constraints in multispecific therapy, showing improved stability and in vivo efficacy in non-human primates.