Topologically Engineered Tetrahedral Antibody Architectures for Multispecific Therapy
Daniel J. Capon, Larisa Troitskaya, Marina E. Fomin, Malcolm L. Gefter, Ursula Edman, Brendon T. Frank, Benjamin Z. Capon, Jing Jin, Rachel Martinelli, Ginger A. Ferguson, Ramona Vestweber, Cheila Rocha, Berit Roshani, Victor Max Corman, Christian Drosten, , Nelson L.S. Chan
This paper engineers tetrahedral antibodies with a non-planar architecture to overcome steric constraints in multispecific therapy, showing improved stability and in vivo efficacy in non-human primates.
bioRxiv · Mar 23, 2022 · PreprintMolecular Biology