Molecular BiologyCell DiscoveryPeer-reviewed
Molecular Mechanism of pH Sensing and Activation in GPR4 Reveals Proton-Mediated GPCR Signaling
Chongzhao You, Shimeng Guo, Tianwei Zhang…·H. Eric Xu
This study reveals the molecular mechanism of pH sensing and activation in GPR4 through cryo-EM structures, showing proton-driven conformational changes and lipid modulation.
10 citations