Author

Tianyu Gao

ShanghaiTech University

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Biology Disciplines

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Molecular Biology· 2

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:protein structure· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

H. Eric XuiD· 2 shared Xi ChengiD· 2 shared Xinheng HeiD· 2 shared Yi JiangiD· 2 shared Chongzhao YouiD· 1 shared Gong Yang· 1 shared Hualiang JiangiD· 1 shared Jia DuaniD· 1 shared

Activity by Year

2023-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersMolecular Biology

H. Eric XuORCID

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2 papers

Recent·Most cited

Molecular Mechanism of pH Sensing and Activation in GPR4 Reveals Proton-Mediated GPCR Signaling

Chongzhao You, Shimeng Guo, Tianwei Zhang, Xinheng He, Tianyu Gao, Wenwen Xin, Zining Zhu, Yujie Lu, Youwei Xu, Zhen Li, Yumu Zhang, Xi Cheng, Yi Jiang, Xin Xie, H. Eric Xu

This study reveals the molecular mechanism of pH sensing and activation in GPR4 through cryo-EM structures, showing proton-driven conformational changes and lipid modulation.

Cell Discovery · Jun 24, 2025Peer-reviewedMolecular Biology

Structural basis of peptide recognition and activation of endothelin receptors

Yujie Ji, Jia Duan, Qingning Yuan, Xinheng He, Gong Yang, Shengnan Zhu, Kaichun Wu, Wen Hu, Tianyu Gao, Xi Cheng, Hualiang Jiang, H. Eric Xu, Yi Jiang

The paper presents cryo-EM structures of endothelin receptors bound to ligands, revealing their recognition mode and activation mechanism.

Nature Communications · Mar 7, 2023Peer-reviewedMolecular Biology