Author
Chinese Academy of SciencesORCID 0000-0002-8086-5092Unclaimed ORCID profile · follow to get notified of new preprints
4 papers
Recent·Most cited
Xinyue Zhang, Yu Zheng, Heng Liu, Jingjing Hou, Luyu Fan, Xinheng He, Jun Sun, Tao Liu, Jianhui Zhou, Ruxin Lei, Mingyang Li, Wen Hu, Xi Cheng, Sheng Wang, Xin Xie, , Youwen Zhuang
The paper defines the molecular mechanism of graded activation of the dopamine D1 receptor and shows how ligand efficacy is encoded through an activation pathway.
bioRxiv · Jul 29, 2026 · PreprintBiochemistry
Xinyue Zhang, Yujie Lu, Xinheng He, Shimeng Guo, Changyao Li, Yu Wang, Yuan Gao, Juxia Yao, Qingning Yuan, Yinshan Tang, Wen Hu, Zijuan Luo, Kai Wu, Yue Wang, Wanchao Yin, , Heng Liu
This study determines the cryo-EM structures of OXGR1 bound to metabolites, revealing conserved mechanisms for metabolite recognition and receptor activation.
The EMBO Journal · Jun 3, 2026Peer-reviewedMolecular Biology
Chongzhao You, Shimeng Guo, Tianwei Zhang, Xinheng He, Tianyu Gao, Wenwen Xin, Zining Zhu, Yujie Lu, Youwei Xu, Zhen Li, Yumu Zhang, Xi Cheng, Yi Jiang, Xin Xie, H. Eric Xu
This study reveals the molecular mechanism of pH sensing and activation in GPR4 through cryo-EM structures, showing proton-driven conformational changes and lipid modulation.
Cell Discovery · Jun 24, 2025Peer-reviewedMolecular Biology
Jia Duan, Dandan Shen, Tingting Zhao, Shimeng Guo, Xinheng He, Wanchao Yin, Peiyu Xu, Yujie Ji, Li-Nan Chen, Jinyu Liu, Huibing Zhang, Qiufeng Liu, Yi Shi, Xi Cheng, Hualiang Jiang, , Yi Jiang
The paper reports the structures of galanin bound to its receptors and G proteins, revealing the molecular basis for allosteric agonism and G protein subtype selectivity.
Nature Communications · Mar 15, 2022Peer-reviewedMolecular Biology