Cancer BiologybioRxivPreprint
Specific degrader for fusion oncokinase kills tumors and is augmented by bimodal degrader-siRNA
Mahsa Shirani, Ronaldo Shaquille Bowie, Michael D. Tomasini…·Sanford M. Simon
The paper develops a degrader that specifically targets oncogenic fusions in cancer cells, showing efficacy in preclinical models and enhanced therapeutic effect when combined with siRNA.
DOI 10.1101/2025.04.24.650501