Erik Abner

GWAS of Lyme disease identifies five loci and discovers a connection with post-infectious diseases

This study conducts a GWAS of Lyme disease, identifying five genetic loci and linking it to post-infectious diseases like Bell palsy and joint pain.

The genetic architecture of fibromyalgia across 2.5 million individuals

This study identifies 26 risk loci for fibromyalgia through a genome-wide association analysis of 2.5 million individuals, revealing genetic links to neural functions and chronic pain disorders.

Quantifying the contribution of genetic variation to healthcare expenditure across diverse healthcare systems

This study identifies genetic variants associated with healthcare costs across multiple systems, finding polygenic influences and large effects from specific loss-of-function variants.

Genetic architecture of 67 oral diseases and their links to systemic diseases

This study identifies 105 genetic loci associated with 67 oral diseases and finds strong genetic correlations between oral and systemic conditions.

Genetic variants affect diurnal glucose levels throughout the day

The paper identifies genetic variants associated with diurnal glucose levels and their role in type 2 diabetes risk.

Genome-wide association study for circulating metabolic traits in 619,372 individuals

This study performs a large-scale GWAS on 249 metabolic traits in 619,372 individuals, identifying 88,604 associations and using MR to explore causal links between metabolites and diseases.

Circadian rhythms regulate refractive development across species

This study shows that circadian misalignment contributes to myopia across species, with reversible effects in mice and associations in human populations.

From Normal Variation in Sleep to Clinical Sleep Disorders: Genetic Insights from Over One Million Individuals

This study identifies genetic associations for multiple sleep disorders and medications in over 1.6 million individuals, revealing shared and unique genetic factors across sleep traits.

Initial findings from the DecodeME genome-wide association study of myalgic encephalomyelitis/chronic fatigue syndrome

This study conducts a genome-wide association study (GWAS) of ME/CFS, identifying eight genetic loci associated with the disease, suggesting involvement of immune and neurological processes.

Leveraging nationwide health care records in Estonia to identify the genetic background of understudied disease phenotypes

The paper uses Estonian Biobank data to identify genetic loci associated with 5,491 disease phenotypes, finding 3,222 genome-wide significant loci and 754 protein-altering variant-trait associations.

Genome-wide association study of varenicline-aided smoking cessation

This paper conducts a genome-wide association study to identify genetic variants associated with varenicline-aided smoking cessation using electronic health records.

Genome-wide association analysis reveals insights into the molecular aetiology underlying dilated cardiomyopathy

This study identifies 80 genetic loci and 61 effector genes associated with dilated cardiomyopathy through GWAS and integrates transcriptomic data to uncover biological pathways and cellular states involved in the disease.

From Biobanking to Personalized Medicine: the journey of the Estonian Biobank

The paper reviews the Estonian Biobank's role in advancing genomics research and personalized medicine through its comprehensive data and translational focus.

Regulatory variation at serotonin receptor 1F (HTR1F) modulates arousals and risk for sleep apnea

The paper identifies regulatory variation at HTR1F associated with sleep apnea risk and arousals, particularly in non-obese individuals.

Associations between common genetic variants and income provide insights about the socioeconomic health gradient

This study identifies genetic variants associated with income and shows they correlate with health outcomes and educational attainment.

The alpha-2A-adrenergic receptor (ADRA2A) modulates susceptibility to Raynaud's syndrome

This study identifies ADRA2A as a major risk locus for Raynaud's syndrome through genome-wide association analysis and functional validation in vascular smooth muscle cells.

HLA allele-calling using whole-exome sequencing identifies 129 novel associations in 11 autoimmune diseases: a multi-ancestry analysis in the UK Biobank

This study uses whole-exome sequencing to directly call HLA alleles in the UK Biobank, identifying 129 novel associations between HLA alleles and 11 autoimmune diseases.

Comprehensive genome-wide association study of different forms of hernia identifies more than 80 associated loci

This study identifies 81 genetic loci associated with different hernia types using genome-wide association analysis in the UK Biobank.

Genome-wide association study identifies five risk loci for pernicious anemia and implicates the role of HLA-DR15 haplotype

This study identifies five genetic risk loci for pernicious anemia through a genome-wide association analysis and links the disease to the HLA-DR15 haplotype.

Genome-wide study identifies association between HLA-B*55:01 and penicillin allergy

The paper identifies HLA-B*55:01 as a genetic risk factor for penicillin allergy through genome-wide analysis of electronic health records and imputed HLA data.