Author

Michael Lee

Imperial College LondonORCID 0000-0002-0186-4439Unclaimed ORCID profile · follow to get notified of new preprints

Additional preprints under this name without ORCID

Michael Lee3 papers · McGovern Institute for Brain Research

Biology Disciplines

Click to filter author papers

Molecular Biology· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

Click to filter · or open tag

Assay:bulk RNA-seq· 3 Organism:mouse· 2 Approach:statistical model· 2 Assay:ATAC-seq· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:fine-mapping· 1 Research Focus:gene regulatory network inference· 1

Frequent Co-Authors

Paul J.R. BartoniD· 3 shared Stuart A. CookiD· 3 shared Anissa Anindya WidjajaiD· 2 shared Chelsie Villanueva-HayesiD· 2 shared Ekhlas RahmaniD· 2 shared Ivan AndrewiD· 2 shared Katie O’Fee· 2 shared Konstantinos VanezisiD· 2 shared

Activity by Year

2023-2024 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

3 shared papersMolecular Biology

Paul J.R. BartonORCID

Mutual co-authors in cluster

Author profile →

3 papers

Recent·Most cited

Genetic & Genomic MedicineNature GeneticsPeer-reviewedNov 21, 2024

Genome-wide association analysis reveals insights into the molecular aetiology underlying dilated cardiomyopathy

Sean Lee Zheng, Albert Henry, Douglas Ewan Cannie…·Patrick T. Ellinor

This study identifies 80 genetic loci and 61 effector genes associated with dilated cardiomyopathy through GWAS and integrates transcriptomic data to uncover biological pathways and cellular states involved in the disease.

68 citationstop 1%

humanbulk RNA-seq

𝕏 PostBluesky

Molecular BiologybioRxivPreprintSep 30, 2023

Interleukin 11 therapy causes acute heart failure and its use in patients should be reconsidered

Mark D. Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes…·Stuart A. Cook

This paper identifies direct cardiomyocyte toxicities of IL11 therapy, showing it causes acute heart failure by activating JAK/STAT3, which questions its continued use in patients.

2 citations

mousebulk RNA-seq

𝕏 PostBluesky

Molecular BiologyInternational Journal of Molecular SciencesPeer-reviewedAug 20, 2023

Cardiomyocyte-restricted expression of IL11 causes cardiac fibrosis, inflammation, and dysfunction.

Mark D. Sweeney, Katie O’Fee, Chelsie Villanueva-Hayes…·Stuart A. Cook

This study shows that IL11 expression in cardiomyocytes causes cardiac fibrosis, inflammation, and dysfunction, contradicting previous reports of its anti-fibrotic effects.

29 citationstop 3%

mousebulk RNA-seq

𝕏 PostBluesky