Quantitative live cell imaging of a tauopathy model enables the identification of a polypharmacological drug candidate that restores physiological microtubule regulation
Luca Pinzi, Christian Conze, Nicolò Bisi, Gabriele Dalla Torre, Ahmed Soliman, Nanci Monteiro-Abreu, Nataliya I. Trushina, Andrea Krusenbaum, Maryam Khodaei Dolouei, Andrea Hellwig, Michael S. Christodoulou, Daniele Passarella, Lidia Bakota, Giulio Rastelli, Roland Brandt
The paper uses live-cell imaging to identify a drug candidate that restores microtubule regulation by targeting tau aggregation and phosphorylation in a tauopathy model.
Nature Communications · Feb 23, 2024Peer-reviewedNeuroscience