Structure and function of an intermediate GPCR-G protein complex
Maxine Bi, Xudong Wang, Jinan Wang, Jun Xu, Sun Wenkai, Victor Ayo Adediwura, Yinglong Miao, Yifan Cheng, Libin Ye
The paper resolves the structure of an intermediate GPCR-G protein complex and shows it initiates nucleotide exchange without progressing to the fully activated state, providing insights into GPCR signaling complexity.
Nature Communications · Jan 28, 2025Peer-reviewedBiophysics