Yifan Cheng

This study identifies structural adaptability in HIV-2 Vif that enables broad antagonism of APOBEC3G through conformational selection.

This study reveals that INO80 reorients on a nucleosome upon ATP hydrolysis, enabling DNA translocation through a unique mechanism distinct from other chromatin remodelers.

CryoROLE extracts continuous conformational dynamics from cryo-EM data by analyzing relative domain orientations, revealing hidden protein motions relevant to function.

This study identifies Rpl3l as a muscle-specific ribosomal protein that regulates chromatin insulation in atrial cardiomyocytes, linking genome structure to cardiac rhythm stability.

The paper presents Cryo-EM structures of the CRL2-ZYG11B complex with substrates, revealing how ZYG11B recognizes and ubiquitinates Gly/N-degrons to activate the NLRP1 inflammasome.

This paper designs a targeted autoantibody degrader to treat neurologic diseases by specifically clearing pathogenic autoantibodies while preserving the immune system.

The paper identifies a domain-swapped architecture in latent TGF-β, crucial for its activation through dynamic allostery.

The paper identifies a conserved loop in herpesvirus proteases that controls dimerization and enzyme activity, presenting a new target for antiviral inhibitors.

This study shows HMGB1 counteracts linker histone H1 by distorting nucleosomal DNA and contacting H1's C-terminal tail, enabling co-occupancy and dynamic chromatin states.

The paper determines the cryo-EM structure of the HIV-1 nuclear export complex, revealing how RNA interacts with Crm1 through specific binding sites and contacts.

This study uses cryo-EM and HDX-MS to reveal structural changes in TRPM8 channels that underlie cold sensitivity and menthol activation.

This paper introduces a deconvolution method called AR-Decon to improve the quality of cryo-EM maps and shows it is robust and broadly applicable.

The paper resolves the structure of an intermediate GPCR-G protein complex and shows it initiates nucleotide exchange without progressing to the fully activated state, providing insights into GPCR signaling complexity.

The paper identifies 245 putative RNA structural switches in the human transcriptome using a computational and experimental approach, validates one with DMS-MaPseq and cryo-EM, and shows its regulation by trans factors and nonsense-mediated decay.

The paper measures the mechanical properties of NompC gating springs and finds nonlinear compliance that may regulate mechanotransduction sensitivity.

The paper describes a method combining CRISPR/Cas and fluorescence cell sorting to efficiently tag and purify endogenous human proteins for structural analysis using cryo-EM.