Author

Richard D. Walton

Université de BordeauxORCID 0000-0002-9687-2545Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Assay:imaging· 4 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Organism:human· 2 Organism:mouse· 2 Approach:biophysical modeling· 1 Assay:bulk RNA-seq· 1 Research Focus:cell signaling & trafficking· 1

Frequent Co-Authors

Fanny VaillantiD· 2 shared Marion ConstantiniD· 2 shared Olivier BernusiD· 2 shared Philippe PasdoisiD· 2 shared Sabine CharroniD· 2 shared Alice J. FrancisiD· 1 shared Alicia D’SouzaiD· 1 shared Arash ForodighasemabadiiD· 1 shared

Activity by Year

2025-2026 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 21 mutual co-author links

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2 shared papersPhysiology

Fanny VaillantORCID

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Author profile →

4 papers

Recent·Most cited

Cell-Type-Resolved Transcriptomics Defines Stable and Accessible Markers of the Cardiac Purkinje Fiber in Sheep and Human Translation

Sabine Charron, Néstor Pallares‐Lupon, Marion Constantin, Jason D. Bayer, Philippe Pasdois, Fanny Vaillant, Richard D. Walton

Laser-capture RNA-seq of sheep Purkinje fibers yields a 331-gene enriched panel; thirteen of sixteen ranked candidates confirmed by RT-qPCR, and CNTN5 is Purkinje-enriched in sheep and human.

bioRxiv · Aug 25, 2026 · PreprintPhysiology✦ In-depth digest

Structural Characterization of Cardiac Purkinje Fibers Using Inhomogeneous Magnetization Transfer (ihMT): A proof of Concept MRI-Histology Approach

Arash Forodighasemabadi, Evgenios Kornaropoulos, Marion Constantin, Lucas Soustelle, Fanny Vaillant, Jude Leury, Richard D. Walton, Olivier Bernus, Bruno Quesson, Olivier M. Girard, Guillaume Duhamel, Julie Magat

This paper uses ihMT MRI to differentiate subregions of cardiac Purkinje fibers in sheep hearts, showing higher ihMTR in free-running PF compared to insertion points and myocardium, with histology confirming collagen differences.

NMR in Biomedicine · Apr 19, 2026Peer-reviewedBiophysics

Resident cardiac macrophages are not required for normal atrioventricular node conduction

Sami Al-Othman, Yakun Wu, Pierre Fontanaud, Franz K Puttur, David Conesa, Chelsea Zhu, Sacha Moore, Roman Tikhomirov, Alice J. Francis, Sooraj Nair, Rasheda A. Chowdhury, Mubassher Husain, Joseph J. Boyle, Delvac Oceandy, Steven Niederer, , Alicia D’Souza

This study challenges the role of resident cardiac macrophages in AV node conduction by showing no evidence of Cx43-mediated coupling and no effect of macrophage depletion on AV electrical activity.

bioRxiv · Feb 12, 2026 · PreprintPhysiology

AI-based identification of cardiac Purkinje fiber cells isolated from whole adult sheep hearts

Sébastien Chaigne, Thomas Hof, Kristell Mimoun, Ayoub El Ghebouli, Sabine Charron, Fabien Brette, Frank S. Choveau, Philippe Pasdois, Catherine Rücker‐Martin, David Benoîst, Romain Guinamard, Michel Haı̈ssaguerre, Richard D. Walton, Olivier Bernus

This paper develops a deep learning-based method to isolate and classify Purkinje fiber cells from adult sheep hearts using imaging data and validation techniques.

bioRxiv · May 13, 2025 · PreprintPhysiology