Author

Steven Niederer

Imperial College LondonORCID 0000-0002-4612-6982Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 4 Approach:statistical model· 3 Research Focus:benchmarking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:imaging· 2 Organism:mouse· 2 Approach:Bayesian inference· 1

Frequent Co-Authors

Alice J. FrancisiD· 2 shared Alicia D’SouzaiD· 2 shared Mark R. BoyettiD· 2 shared Matteo Elia MangoniiD· 2 shared Michael A. ColmaniD· 2 shared Roman TikhomiroviD· 2 shared Sami Al-OthmaniD· 2 shared Abdul QayyumiD· 1 shared

Activity by Year

2026-2026 · peak 5/yr

Co-Author Collaboration Network

10 top collaborators · 36 mutual co-author links

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2 shared papersPhysiology

Alice J. FrancisORCID

Mutual co-authors in cluster

Author profile →

5 papers

Recent·Most cited

OpenCRS: an open-source regulated human cardiorespiratory model with large-scale calibration and global sensitivity analysis at rest and during exercise

Sheng‐Ya Wang, Harry Saxton, Maximilian Balmus, Steven Niederer

OpenCRS is a cardiorespiratory model calibrated with global sensitivity analysis to identify influential parameters and mechanisms during rest and exercise.

bioRxiv · Sep 21, 2026 · PreprintSystems Biology

The Ca2+-Sensitivity of Contraction is Increased in the Left Atrium and Left Ventricle of Patients with Ischemic Heart Failure

Gregory N. Milburn, Chloe I Roth, Jania Bell, Austin G. Wellette‐Hunsucker, Marziyeh Pakbaz, Alexandre Lewalle, Steven Niederer, Kenneth S. Campbell

This study examines changes in calcium sensitivity and contractile properties of left atrial and ventricular myocardium in ischemic heart failure, finding increased calcium sensitivity and altered kinetics in the left atrium.

bioRxiv · Jul 1, 2026 · PreprintPhysiology

Endurance exercise remodels pulmonary vein sleeve myocytes and promotes a proarrhythmic atrial substrate

Luca Soattin, Leila Topál, Roman Tikhomirov, Daniele Lagomarsino-Oneto, Sami Al-Othman, Angela W C Lee, Sushant Saluja, Tibor Hornyik, Zoltán Husti, Jenő Antal Pintér, Aiman Saleh A. Mohammed, Matthew Smith, Alice J. Francis, Megan K. McKie, Eleonora Torre, , Alicia D’Souza

This study shows endurance exercise increases proarrhythmic remodeling in pulmonary vein sleeve myocytes and the PV-LA junction, contributing to atrial fibrillation susceptibility in athletes.

European Heart Journal · Apr 24, 2026Peer-reviewedPhysiology

A Cohort-Based Global Sensitivity Benchmark of MRI-Derived Whole-Heart Electromechanical Models in Healthy Hearts

Shahrokh Rahmani, Jim Pouliopoulos, Angela Lee, Rosie K. Barrows, José Alonso Solís-Lemus, Marina Strocchi, Cristóbal Rodero, Abdul Qayyum, S. Samaneh Lashkarinia, Caroline H. Roney, Christoph M. Augustin, Gernot Plank, Diane Fatkin, Andrew Jabbour, Steven Niederer

The paper benchmarks global sensitivity analysis of whole-heart electromechanical models across five healthy subjects, finding haemodynamic parameters dominate cardiac function despite anatomical variation.

bioRxiv · Mar 30, 2026 · PreprintSystems Biology

Resident cardiac macrophages are not required for normal atrioventricular node conduction

Sami Al-Othman, Yakun Wu, Pierre Fontanaud, Franz K Puttur, David Conesa, Chelsea Zhu, Sacha Moore, Roman Tikhomirov, Alice J. Francis, Sooraj Nair, Rasheda A. Chowdhury, Mubassher Husain, Joseph J. Boyle, Delvac Oceandy, Steven Niederer, , Alicia D’Souza

This study challenges the role of resident cardiac macrophages in AV node conduction by showing no evidence of Cx43-mediated coupling and no effect of macrophage depletion on AV electrical activity.

bioRxiv · Feb 12, 2026 · PreprintPhysiology