Eleanor T. Coffey

This study uses AAV vectors to target specific neuronal populations and shows that JNK inhibition has distinct anxiolytic effects depending on the targeted cells.

NMFBatch reduces technical variation and preserves biological structure in proteomics data through batch correction and imputation.

This study shows rotenone induces phospho-signaling changes in neural cells, which are mediated by Lrrk2, affecting microtubules, cilia, and proteostasis in Parkinson's disease.

The paper identifies phosphoproteome markers regulated by JNK inhibition in mouse hippocampus linked to anxiety-like behavior.

LimROTS improves differential expression analysis in proteomics by combining empirical Bayes and reproducibility-optimized statistics for better accuracy and reproducibility.

This study shows that JNK1 suppresses β3-containing GABAAR surface expression via GIT1 phosphorylation, affecting inhibitory tone and synaptic function.

The paper identifies translational repression of proteostasis regulators in fibroblasts from both sporadic and LRRK2-G2019S Parkinson's patients using proteomics.

PhosPiR automates phospho-proteomic analysis by integrating multiple R packages to provide data cleaning, statistical testing, enrichment analysis, and visualization for high-dimensional mass spectrometry data.

This study shows that LRRK2 activity suppresses protein synthesis in Parkinson's disease, with inhibition restoring normal translation in patient fibroblasts.