Prasannakumar Deshpande

Targeting distinct neuronal populations with AAV vectors reveals neurogenesis-associated anxiolytic effects of JNK inhibition

This study uses AAV vectors to target specific neuronal populations and shows that JNK inhibition has distinct anxiolytic effects depending on the targeted cells.

Environmental Toxin Rotenone Drives LRRK2-Mediated Microtubule, Cilia and Proteostasis Disruption in Parkinson's Disease Model

This study shows rotenone induces phospho-signaling changes in neural cells, which are mediated by Lrrk2, affecting microtubules, cilia, and proteostasis in Parkinson's disease.

Identifying JNK-regulated phosphoproteome markers of anxiety-like behaviour in mouse hippocampus

The paper identifies phosphoproteome markers regulated by JNK inhibition in mouse hippocampus linked to anxiety-like behavior.

JNK regulates β3-containing GABAAR expression at the cell surface via the receptor clustering protein GIT1 (ArfGAP1)

This study shows that JNK1 suppresses β3-containing GABAAR surface expression via GIT1 phosphorylation, affecting inhibitory tone and synaptic function.

Regulators of proteostasis are translationally repressed in fibroblasts from sporadic and LRRK2-G2019S Parkinson's patients

The paper identifies translational repression of proteostasis regulators in fibroblasts from both sporadic and LRRK2-G2019S Parkinson's patients using proteomics.

Protein synthesis is suppressed in sporadic and familial Parkinson's Disease by LRRK2

This study shows that LRRK2 activity suppresses protein synthesis in Parkinson's disease, with inhibition restoring normal translation in patient fibroblasts.