Author

Valentina Siino

Lund UniversityORCID 0000-0002-0489-6380Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Bioinformatics· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 3 Approach:experimental assay· 3 Organism:mouse· 3 Assay:proteomics· 3 Approach:statistical model· 3 Research Focus:benchmarking· 1 Assay:bulk RNA-seq· 1 Research Focus:cell type annotation· 1

Frequent Co-Authors

Eleanor T. CoffeyiD· 3 shared Peter JamesiD· 3 shared Prasannakumar DeshpandeiD· 3 shared Ye HongiD· 3 shared Artemis Varidaki· 2 shared Christel SouranderiD· 2 shared Dani FlinkmaniD· 2 shared Annika SchäferiD· 1 shared

Activity by Year

2020-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 39 mutual co-author links

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3 shared papersNeuroscience

Eleanor T. CoffeyORCID

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Author profile →

4 papers

Recent·Most cited

Identifying JNK-regulated phosphoproteome markers of anxiety-like behaviour in mouse hippocampus

Ye Hong, Valentina Siino, Dani Flinkman, Prasannakumar Deshpande, Sylvia Ortega Martinez, Veronica Fagerholm, Artemis Varidaki, Pierre Heemeryck, Christel Sourander, Peter James, Eleanor T. Coffey

The paper identifies phosphoproteome markers regulated by JNK inhibition in mouse hippocampus linked to anxiety-like behavior.

Neurobiology of Disease · Nov 29, 2025Peer-reviewedNeuroscience

JNK regulates β3-containing GABAAR expression at the cell surface via the receptor clustering protein GIT1 (ArfGAP1)

Artemis Varidaki, Prasannakumar Deshpande, Elina I. Nagaeva, Annika Schäfer, Christel Sourander, Ye Hong, Soroush Abyari, Valentina Siino, Christoffer Lagerholm, Peter James, Esa R. Korpi, Eleanor T. Coffey

This study shows that JNK1 suppresses β3-containing GABAAR surface expression via GIT1 phosphorylation, affecting inhibitory tone and synaptic function.

bioRxiv · Jan 22, 2025 · PreprintNeuroscience

OmicLoupe: Facilitating biological discovery by interactive exploration of multiple omic datasets and statistical comparisons

Jakob Willforss, Valentina Siino, Fredrik Levander

OmicLoupe enables interactive exploration and statistical comparison of multiple omic datasets to identify technical issues and biological patterns.

BMC Bioinformatics · Mar 4, 2021Peer-reviewedBioinformatics

Protein synthesis is suppressed in sporadic and familial Parkinson's Disease by LRRK2

Prasannakumar Deshpande, Dani Flinkman, Ye Hong, Elena Goltseva, Valentina Siino, Lihua Sun, Sirkku A. Peltonen, Laura L. Elo, Valtteri Kaasinen, Peter James, Eleanor T. Coffey

This study shows that LRRK2 activity suppresses protein synthesis in Parkinson's disease, with inhibition restoring normal translation in patient fibroblasts.

The FASEB Journal · Sep 14, 2020Peer-reviewedNeuroscience