Berton A. Earnshaw

This paper builds and benchmarks perturbative maps of transcriptional and morphological data, demonstrating their utility for discovering new biology and highlighting the importance of standardized frameworks.

RxRx3 provides a large-scale high-content screening dataset combining CRISPR knockouts and small molecule treatments to enable machine learning research and biological discovery.

In an image-based screen of 1,670 compounds in SARS-CoV-2-infected human renal epithelial cells, remdesivir was the only antiviral with strong efficacy; chloroquine and hydroxychloroquine showed no benefit.