Marta M. Fay

This paper builds and benchmarks perturbative maps of transcriptional and morphological data, demonstrating their utility for discovering new biology and highlighting the importance of standardized frameworks.

The paper identifies a proximity bias in CRISPR-Cas9 knockouts, showing phenotypic similarity between unrelated genes on the same chromosome arm, and proposes a correction method.

RxRx3 provides a large-scale high-content screening dataset combining CRISPR knockouts and small molecule treatments to enable machine learning research and biological discovery.