Unravelling drug resistant proteotypes through phenotype-resolved proteomics of single-cell derived colonies
Di Qin, Ridhima Das, Simon Schallenberg, Kristoffer Riecken, Ingeborg Tinhofer, Fabian Coscia
This paper introduces PhenoSCoP, a framework that uses single-cell proteomics and microscopy to identify drug-resistant proteotypes in cancer cells and their progression in patient tissues.
bioRxiv · Oct 11, 2025 · PreprintSystems Biology