Jose Nimo

Spatialproteomics - an interoperable toolbox for analyzing highly multiplexed fluorescence image data

The paper introduces spatialproteomics, a Python toolbox for analyzing highly multiplexed fluorescence images, demonstrating its use on lymph node and lymphoma data.

OpenDVP: An experimental and computational framework for community-empowered deep visual proteomics

The paper introduces openDVP, a framework for deep visual proteomics, demonstrating its application in three tissue studies to integrate spatial single-cell phenotypes with proteomic data.

Maternal smoking in early pregnancy disrupts placental function through syncytiotrophoblast and macrophage dysregulation.

This study shows maternal smoking disrupts placental function by altering syncytiotrophoblast and macrophage biology, leading to fetal growth restriction.

Spatial omics of acute myocardial infarction reveals a novel mode of immune cell infiltration

This study maps acute murine myocardial infarction with subcellular resolution, identifying a novel endocardial route of immune cell infiltration and vWF as a key mediator.

A framework for ultra-low input spatial tissue proteomics

This paper introduces a workflow for ultra-low input spatial tissue proteomics, demonstrating high protein quantification from single cells and microregions in murine and human tissues.

High-resolution molecular atlas of a lung tumor in 3D

This paper presents a 3D spatial atlas of a human lung carcinoma, revealing tumor microenvironment niches and their associated immune interactions and survival outcomes.

Disturbed trophoblast transition links preeclampsia progression from placenta to the maternal syndrome

The paper identifies a disrupted trophoblast transition in preeclampsia, linking placental pathology to maternal syndrome through multi-omics profiling and in vitro analyses.