Genome-wide classification of tumor-derived reads from bulk long-read sequencing
Toby M. Baker, Nedas Matulionis, Cassidy L. Andrasz, Daniel S. Gerke, Natalia Garcia-Dutton, David Atkinson, Kami Chiotti, Selina Wu, Suchita Lulla, Jieun Oh, Helena K. Winata, Rongrong Huang, Jenny Lester, Beth Y. Karlan, Paul T. Spellman
ROCIT classifies tumor or non-tumor origin of reads from bulk long-read sequencing with high accuracy, improving somatic variant calling in tumors.
bioRxiv · Mar 5, 2026 · PreprintBioinformatics