Genomic and single-cell characterization of patient-derived tumor organoid models of head and neck squamous cell carcinoma
Jung Hyun Um, Yueyuan Zheng, Qiong Mao, Chehyun Nam, Hua Zhao, Yoon Woo Koh, Su‐Jin Shin, Young Min Park, De‐Chen Lin
This study establishes patient-derived tumor organoids (PDOs) from 31 HNSCC patients, faithfully recapitulating tumor characteristics and predicting cisplatin responses, revealing hEMT-driven resistance and AREG as a therapeutic target.
Cancer Research · Apr 22, 2025Peer-reviewedCancer Biology