Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways
Samantha L. Schaffner, Zinah Wassouf, Diana F. Lázaro, Mary Xylaki, Nicole Gladish, David T S Lin, Julia L. MacIsaac, Katia E. Ramadori, Julia Maria Schulze-Hentrich, Tiago F. Outeiro, Michael Steffen Kobor
This study identifies DNA methylation and hydroxymethylation changes in dopaminergic neurons overexpressing alpha-synuclein variants, linking them to altered gene expression in PD-related pathways.
bioRxiv · Jun 12, 2021 · PreprintGenomics