Diana F. Lázaro

Synphilin-1 as a modulator of aSyn assembly

This study models aSyn assemblies in living cells and shows that Sph1-aSyn interactions influence inclusion formation, morphology, and localization, providing insights into protein aggregation and potential therapeutic strategies.

Alpha-synuclein induces epigenomic dysregulation of glutamate signaling and locomotor pathways

This study identifies DNA methylation and hydroxymethylation changes in dopaminergic neurons overexpressing alpha-synuclein variants, linking them to altered gene expression in PD-related pathways.

Super-resolution microscopy informs on the molecular architecture of alpha-synuclein inclusions in model systems and in the human brain

This study uses super-resolution microscopy to examine the molecular structure of alpha-synuclein inclusions in cell models and human brain tissue, revealing conserved patterns and shapes.

Doxycycline inhibits α-synuclein-associated pathologies in vitro and in vivo

This study shows doxycycline reduces α-synuclein aggregation and oxidative stress in vitro and in vivo, suggesting it could treat synucleinopathies like Parkinson's disease.