CHIR99021 causes inactivation of Tyrosine Hydroxylase and depletion of dopamine in rat brain striatum
Sally Hamdon, Pol Fernandez-Gonzalez, Muhammad Yusof Omar, Marta González-Sepúlveda, Jordí Ortiz, Carles Gil
This study shows CHIR99021 inhibits tyrosine hydroxylase and reduces dopamine in rat striatum, suggesting potential therapeutic use and caution in clinical trials.
Neuropharmacology · Oct 14, 2023Peer-reviewedNeuroscience