Marta González-Sepúlveda

This study identifies a bidirectional pathogenic relationship between alpha-synuclein and neuromelanin in Parkinson's disease, showing they promote each other's accumulation and neuronal loss.

This study identifies age-dependent neuroinflammatory changes in NM-containing neurons linked to neurodegeneration, with GPNMB as a conserved protective factor in Parkinson's disease.

LRRK2 G2019S iPSC-derived microglia exposed to neuromelanin, but not α-synuclein fibrils, reduce healthy dopaminergic neuron numbers in co-culture; ivermectin prevents this, and post-mortem midbrain supports it.

This paper creates a transgenic mouse model that mimics human neuromelanin accumulation in catecholaminergic neurons, leading to age-related neurodegenerative deficits.

This study shows CHIR99021 inhibits tyrosine hydroxylase and reduces dopamine in rat striatum, suggesting potential therapeutic use and caution in clinical trials.

This study reduces age-related neuromelanin accumulation in a humanized rodent model, mitigating Parkinson's disease features by preserving dopamine homeostasis and neuronal integrity.