Author

Hana Fakim

Centre Hospitalier de l’Université de MontréalORCID 0000-0002-9751-7908Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 1

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Assay:bulk RNA-seq· 1 Research Focus:cell-cell communication· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein structure prediction· 1 Approach:statistical model· 1

Frequent Co-Authors

Alicia F. DubinskiiD· 1 shared Alyssa N. CoyneiD· 1 shared Andréanne Lacombe· 1 shared Anna‐Leigh BrowniD· 1 shared Arash Meghdadi Esfahani· 1 shared Asmita GhoshiD· 1 shared Carolane Fauchon· 1 shared Christine Vande VeldeiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

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10 top collaborators · 45 mutual co-author links

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1 shared paperNeuroscience

Alicia F. DubinskiORCID

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1 paper

Recent·Most cited

TDP-43 pathology triggers SRRM4-dependent cryptic splicing of G3BP1 in ALS/FTD

Hana Fakim, Asmita Ghosh, Emmanuel Amzallag, Yehuda Matan Danino, Valérie Triassi, Anna‐Leigh Brown, Nanu Pal, Jade-Emmanuelle Deshaies, Alicia F. Dubinski, Andréanne Lacombe, Carolane Fauchon, Arash Meghdadi Esfahani, Karen Ling, Frank Rigo, Paymaan Jafar‐Nejad, , Christine Vande Velde

The paper shows that TDP-43 pathology causes a cryptic exon in G3BP1 to be included in neurons, leading to a protein that disrupts stress granule dynamics in ALS/FTD.

bioRxiv · Sep 17, 2025 · PreprintNeuroscience