TDP-43 pathology is linked to motor neuron loss and is independent of stress granules in vivo
Alicia F. Dubinski, Ala Ferdi, Mariam Choughari, Holly Spence, Arpita Adhikary, Carolane Fauchon, Melissa Touati, Myriam Gagné, Martha Liu, Sarah Peyrard, Jenna Gregory, Christine Vande Velde
This study shows TDP-43 pathology occurs independently of stress granules in motor neurons, challenging existing models of TDP-43 pathogenesis.
bioRxiv · Apr 14, 2026 · PreprintNeuroscience