Author

Mario H. Losen

Maastricht UniversityORCID 0000-0002-9761-0002Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Research Focus:host-pathogen & immune response· 2 Research Focus:cell signaling & trafficking· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Organism:mouse· 1 Organism:rat· 1

Frequent Co-Authors

Anja Kristina SchöttleriD· 2 shared Britt Arets· 2 shared Marina Mané-Damas· 2 shared Pilar Martínez‐MartíneziD· 2 shared David J. EyermaniD· 1 shared Erdem TüzüniD· 1 shared Erik Richardson· 1 shared Lukas ScheibleriD· 1 shared

Activity by Year

2025-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 40 mutual co-author links

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2 shared papersImmunology

Anja Kristina SchöttlerORCID

Mutual co-authors in cluster

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2 papers

Recent·Most cited

Complement inhibition by C3-siRNA treatment prevents AChR loss and reduces complement activation in the rat Passive Transfer Myasthenia Gravis (PTMG)

Anja Kristina Schöttler, Marina Mané-Damas, Britt Arets, Marc H. De Baets, Sandra M.H. Claessen, Tara Barbour, Erik Richardson, David J. Eyerman, Lukas Scheibler, Mario H. Losen, Pilar Martínez‐Martínez

C3-siRNA treatment in PTMG rats reduces AChR loss and MAC deposition, improving muscle function and suggesting complement inhibition as a therapeutic strategy for AChR-MG.

bioRxiv · Aug 31, 2025 · PreprintImmunology

Hock immunization: a refined alternative for developing Experimental Autoimmune Myasthenia Gravis (EAMG) in mice.

Marina Mané-Damas, Anja Kristina Schöttler, Tanya Mohile, Britt Arets, Erdem Tüzün, Mario H. Losen, Pilar Martínez‐Martínez

This study compares hock immunization to footpad immunization in a mouse model of EAMG, finding similar disease outcomes with reduced discomfort using hock injections.

Scientific Reports · Aug 29, 2025Peer-reviewedImmunology