Activation of neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain
Adrien Tassou, Maxime Thouaye, Damien Gilabert, Antoine Jouvenel, Jean-Philippe Leyris, Corinne Sonrier, Lucie Diouloufet, Ilana Méchaly, Sylvie Mallié, Juliette Bertin, Myriam Chentouf, Madeline Neiveyans, Martine Pugnière, Pierre Martineau, Bruno Robert, , Cyril Rivat
This study shows that repeated peripheral nerve injury promotes exaggerated pain and mood disorders, which are linked to spinal microglial activation, and that FLT3 inhibition can prevent these effects.
Progress in Neurobiology · Jan 1, 2022Peer-reviewedNeuroscience