Pierre Martineau

Selective targeting of RalA with intrabodies impairs Triple Negative Breast Cancer metastasis

This paper develops RalA-specific intrabodies that inhibit mitochondrial fission and extracellular vesicle secretion, reducing metastasis in a TNBC mouse model.

Characterization of the p38α MAPK allosteric inhibition by a single chain Fv antibody

This paper identifies a single-chain Fv antibody that allosterically inhibits p38α MAPK by binding to a site distinct from the ATP-binding pocket, reducing inflammation in THP-1 cells.

scFv intrabody targeting wildtype TDP-43 presents protective effects in a cellular model of TDP-43 proteinopathy

The paper identifies two scFv intrabodies that bind to wildtype TDP-43 and show protective effects in a cellular model of TDP-43 proteinopathy.

Control of physical and biochemical parameters influencing exogeneous cargo protein association to extracellular vesicles using lipid anchors enables high loading and effective intracellular delivery

This study identifies critical parameters for lipid-anchored protein loading into extracellular vesicles and demonstrates efficient intracellular delivery.

Activation of neuronal FLT3 promotes exaggerated sensorial and emotional pain-related behaviors facilitating the transition from acute to chronic pain

This study shows that repeated peripheral nerve injury promotes exaggerated pain and mood disorders, which are linked to spinal microglial activation, and that FLT3 inhibition can prevent these effects.