Cyril Rivat

The paper develops a stable HEK293 cell line expressing FLT3 for pharmacological studies and shows it effectively models FLT3 signaling and response to inhibitors.

This study identifies Raf-MEK-ERK signaling as a pathway linking FLT3 activation to nociceptor sensitization and reduced morphine efficacy in rodents.

This study shows FL/FLT3 signaling increases mechanical pain hypersensitivity via IL-1β in male mice, with IL-1β mediating FL's effects on TRPV1 and pain responses.

This study shows that inhibiting FLT3 signaling preserves opioid analgesia while preventing tolerance and hyperalgesia in chronic pain models.

This study shows that repeated peripheral nerve injury promotes exaggerated pain and mood disorders, which are linked to spinal microglial activation, and that FLT3 inhibition can prevent these effects.

This study shows that dopamine D2 receptors in the extended amygdala are crucial for switching between passive and active defensive behaviors in response to threats.

This study shows that AAV2/9-mediated PMP22 silencing in rats prevents CMT1A disease and identifies skin biomarkers as potential outcome measures.