Jean-Philippe Leyris

The paper develops a stable HEK293 cell line expressing FLT3 for pharmacological studies and shows it effectively models FLT3 signaling and response to inhibitors.

This study identifies Raf-MEK-ERK signaling as a pathway linking FLT3 activation to nociceptor sensitization and reduced morphine efficacy in rodents.

This study shows FL/FLT3 signaling increases mechanical pain hypersensitivity via IL-1β in male mice, with IL-1β mediating FL's effects on TRPV1 and pain responses.

This study shows that inhibiting FLT3 signaling preserves opioid analgesia while preventing tolerance and hyperalgesia in chronic pain models.

This study shows that repeated peripheral nerve injury promotes exaggerated pain and mood disorders, which are linked to spinal microglial activation, and that FLT3 inhibition can prevent these effects.