This study shows that BAP1 deletion in hepatocytes leads to an inflammatory transcriptional response and impaired immune cell recruitment in the liver.

bioRxiv · Oct 31, 2025 · PreprintGenetics

Aberrant miR-29 is a predictive feature of severe phenotypes in pediatric Crohn's disease

Alexandria J. Shumway, Michael T. Shanahan, Émilie Hollville, Kevin Chen, Caroline Beasley, Jonathan Villanueva, Sara Albert, Grace Lian, Moises R. Cure, Matthew R. Schaner, Lee‐Ching Zhu, Surekha Bantumilli, Mohanish Deshmukh, Terrence S. Furey, Shehzad Z. Sheikh, Praveen Sethupathy

The paper identifies miR-29 as a predictive marker for severe phenotypes in pediatric Crohn's disease through miRNA analysis and validation in mice and human patients.

JCI Insight · Feb 21, 2024Peer-reviewedGenomics

Linking Gene Expression to Clinical Outcomes in Pediatric Crohn's Disease Using Machine Learning

Kevin A. Chen, Nina C. Nishiyama, Meaghan M. Kennedy Ng, Alexandria J. Shumway, Chinmaya U. Joisa, Matthew R. Schaner, Grace Lian, Caroline Beasley, Lee‐Ching Zhu, Surekha Bantumilli, Muneera Rehana Kapadia, Shawn M. Gomez, Terrence S. Furey, Shehzad Z. Sheikh

The paper uses machine learning to predict clinical outcomes in pediatric Crohn's disease by analyzing gene expression from ileal and colonic tissues.

Scientific Reports · Feb 1, 2024Peer-reviewedBioinformatics