Jesse R. Raab

The paper assesses regulatory activity of cortical structure-associated variants using MPRA in human neural progenitor cells, identifying 918 variants with regulatory potential and showing condition-dependent effects.

This study shows vandetanib enhances tamoxifen sensitivity in ER+ breast cancer by reprogramming ER gene regulation and kinase networks, identifying adaptive resistance pathways and response signatures.

This study identifies the cBAF complex as a driver of sorafenib resistance in liver cancer by disrupting hepatocyte lineage identity and promoting a mesenchymal drug-tolerant state.

The paper shows that arginine methylation of BAF155 enhances its interaction with RNA processing factors, affecting nascent transcription at promoters.

The paper identifies chromatin features distinguishing injury-responsive from state-stabilizing transcriptional programs in hybrid hepatocytes using multi-omics data.

This study identifies the menin-MLL1 complex as essential for HCC survival and shows it cooperates with NF-Y to regulate oncogenic gene transcription.

This study shows that BAP1 deletion in hepatocytes leads to an inflammatory transcriptional response and impaired immune cell recruitment in the liver.

The paper expands detection of BAP1 alterations in cancer using multi-omic analyses and identifies a transcriptional signature linked to BAP1 disruption and cellular plasticity.

This paper shows that mutant IDH disrupts p53 target gene regulation by altering chromatin states, disabling tumor suppression, and that this effect can be reversed with IDH inhibition.

The paper quantifies chromatin dynamics in intestinal stem cells to identify regulators of differentiation and reveals 5hmC enrichment in absorptive lineage genes.

The paper investigates how the loss of BRG1 or BRM affects chromatin occupancy and transcription, showing cooperative and antagonistic interactions between the two ATPase subunits.