Grace Lian

Transcriptome-wide Differential Expression and Splicing in Inflammatory Bowel Disease Patients

The paper identifies differential expression and splicing in IBD patients, showing distinct molecular mechanisms in CD and UC.

Reference-guided Genome Assembly of Long Non-coding RNA Transcripts reveals Target Genes Associated With Crohn's Disease

The paper identifies differentially expressed lncRNAs in Crohn's disease using genome-guided RNA-seq and links them to nearby protein-coding genes involved in immune response and tissue regeneration.

Fatty Acid Oxidation Suppression Reprograms Fibroblasts in Fibrostenotic Crohns Disease

The paper identifies impaired fatty acid oxidation in fibroblasts from fibrostenotic Crohn's disease patients and links it to intestinal fibrosis.

eQTL in diseased colon tissue identifies novel target genes associated with IBD

The paper identifies novel target genes associated with IBD by analyzing eQTL in diseased colon tissue and comparing them to non-IBD eQTL.

Aberrant miR-29 is a predictive feature of severe phenotypes in pediatric Crohn's disease

The paper identifies miR-29 as a predictive marker for severe phenotypes in pediatric Crohn's disease through miRNA analysis and validation in mice and human patients.

Linking Gene Expression to Clinical Outcomes in Pediatric Crohn's Disease Using Machine Learning

The paper uses machine learning to predict clinical outcomes in pediatric Crohn's disease by analyzing gene expression from ileal and colonic tissues.

Single-cell analysis of colonic epithelium reveals unexpected shifts in cellular composition and molecular phenotype in treatment-naiïve adult Crohn's disease

The paper uses single-cell analysis to compare colonic epithelial cells in Crohn's disease and control patients, revealing shifts in cell composition and gene expression patterns.