Alex J. Guseman

Engineered OAA lectins as selective and sensitive high mannose glycan targeting tools

This paper engineers OAA lectins to selectively bind specific high mannose glycans, enhancing sensitivity and applicability in glycan profiling and antiviral applications.

Glycopolymers stabilize protein folding and protein-protein interactions via enthalpic interactions

This study shows glycopolymers stabilize protein folding and interactions through enthalpic interactions, challenging simple volume exclusion models of crowding.

Tunable multivalent Fe(II)-based glycoassemblies as mimetics for native high-mannose glycans.

This study creates tunable Fe(II)-based glycoassemblies that mimic high-mannose glycans and inhibit their interactions with lectins.

Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions

This study identifies a partially unfolded N-terminal domain intermediate in cataract-associated γD-crystallin variants under native conditions, revealing hydrophobic patches that may contribute to cataract formation.