BiophysicsProceedings of the National Academy of SciencesPeer-reviewed
Cataract-prone variants of γD-crystallin populate a conformation with a partially unfolded N-terminal domain under native conditions
Sara E. Volz, Jadyn R. Malone, Alex J. Guseman…·Susan Marqusee
This study identifies a partially unfolded N-terminal domain intermediate in cataract-associated γD-crystallin variants under native conditions, revealing hydrophobic patches that may contribute to cataract formation.
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