Shani Stern

iPSC-derived extracellular vesicles rescue deficits in human and mouse models of Parkinsons disease

The paper shows that extracellular vesicles from healthy iPSCs can reverse Parkinson's disease-related deficits in human and mouse models.

Extracellular Vesicles from Stem cells Rescue Cellular Phenotypes and Behavioral Deficits in SHANK3-Associated ASD Neuronal and Mouse Models

This study shows that EVs from stem cells can rescue cellular and behavioral deficits in Shank3-deficient models of ASD.

Baicalin ameliorates behavioral and physiological deficits in Gtf2i-duplication mice and modulates synaptic activity in 7q11.23 Duplication Syndrome patient-derived neurons

This study shows that Baicalin treatment reduces behavioral and physiological deficits in Gtf2i-duplication mice and enhances synaptic activity in 7Dup patient-derived neurons.

Brain Extracellular Matrix implications in multiple neurological disorders are revealed through a meta-analysis of transcriptional changes

This study identifies 31 commonly dysregulated genes across seven neurological disorders, enriched in brain ECM pathways, suggesting distinct ECM changes in disease states.

The Effects of Bipolar Disorder Granule Cell Hyperexcitability and Lithium Therapy on Pattern Separation in a Computational Model of the Dentate Gyrus

This study uses a computational model of the dentate gyrus to show that lithium therapy improves pattern separation in bipolar disorder patients only by normalizing spontaneous activity, not by reducing cell excitability.

Divergent Excitability of GABAergic Neurons Derived from Bipolar Disorder Patients Shapes Energy Shifts of Network Dynamics, possibly mimicking mania and depression

This study compares lithium-responsive and non-responsive bipolar disorder patients' GABAergic neurons, showing divergent excitability that drives network state shifts, potentially linked to mood episodes.

Digestive Dimensions of Autism: A Multiscale Exploration of Gut-Brain Interactions

This paper explores the relationship between gastrointestinal issues and autism spectrum disorders, highlighting potential mechanisms and the need for further research.

Dysregulation of Multiple Solute Carrier genes and Metabolic Deficits in SLC1A4-Mutant Human iPSC-Derived Hippocampal Neurons

This study investigates SLC1A4 mutations in human iPSC-derived neurons, revealing metabolic and synaptic deficits linked to amino acid transport dysfunction and neurodevelopmental disorders.

The Impact of Electrophysiological Diversity on Pattern Completion in Lithium Nonresponsive Bipolar Disorder: A Computational Modelling Approach

This paper uses a computational model of the hippocampal CA3 to show that excitability variance in pyramidal cells impairs pattern completion in lithium nonresponsive bipolar disorder patients.

WWOX deficiency impairs neurogenesis and neuronal function in human organoids

This study identifies WWOX mutations' impact on neurogenesis and neuronal function in human organoids, showing gene therapy can restore function.

Seeking Convergence and Divergence between Autism and Schizophrenia using genomic tools and patients' neurons

The paper compares genetic and cellular differences between autism and schizophrenia using GWAS and iPSC-derived neurons, finding shared SNPs and similar synaptic deficits.

Predicting Suicide Risk in Bipolar Disorder patients from Lymphoblastoid Cell Lines genetic signatures

This paper identifies genetic signatures in lymphoblastoid cell lines associated with suicide risk in bipolar disorder patients using RNA sequencing and machine learning.

Monozygotic twins discordant for schizophrenia differ in maturation and synaptic transmission

This study compares neuronal phenotypes from monozygotic twins discordant for schizophrenia, finding differences in synaptic activity and neuronal maturation between affected and unaffected siblings.

Early maturation and hyperexcitability is a shared phenotype of cortical neurons derived from different ASD-associated mutations

The paper shows that cortical neurons from ASD-associated mutations exhibit early maturation and hyperexcitability compared to controls.

The NO Answer for Autism Spectrum Disorder

The paper investigates the role of nitric oxide in autism spectrum disorder, showing that targeting its production reverses ASD-like phenotypes in mouse models and human samples.

Synaptic dysfunction and dysregulation of extracellular matrix-related genes in dopaminergic neurons derived from Parkinson's disease sporadic patients and with GBA1 mutations

This study examines electrophysiological and gene expression changes in dopaminergic neurons from Parkinson's disease patients and those with GBA1 mutations, identifying synaptic dysfunction and ECM pathway dysregulation.

Upregulated extracellular matrix-related genes and impaired synaptic activity in dopaminergic and hippocampal neurons derived from Parkinson's disease patients with PINK1 and PARK2 mutations

Current progress in understanding Schizophrenia using genomics and pluripotent stem cells: A Meta-analytical overview

This paper reviews genomic studies and iPSC-based models of schizophrenia to summarize current progress in understanding its genetic basis and cellular mechanisms.

Intrinsic excitability in layer IV-VI anterior insula to basolateral amygdala projection neurons encodes the confidence of taste valence

The paper shows that intrinsic excitability in layer IV-VI aIC-BLA neurons encodes taste valence confidence, modulated by novelty and valence, during CTA learning and memory retrieval.

Information theory characteristics improve the prediction of lithium response in bipolar disorder patients using an SVM classifier

The paper uses information theory features to improve SVM classification of lithium response in bipolar disorder patients, achieving 99% accuracy in distinguishing responders from non-responders.

Reduced synaptic activity and dysregulated extracellular matrix pathways are common phenotypes in midbrain neurons derived from sporadic and mutation-associated Parkinson's disease patients

The paper compares midbrain neurons from PD patients with mutations and sporadic PD, finding reduced synaptic activity and dysregulated extracellular matrix pathways as common features.

Neonatal neuronal WWOX gene therapy rescues Wwox null phenotypes

This study shows that gene therapy using an AAV vector to restore WWOX expression in neurons rescues multiple neurological defects in Wwox-null mice.

Modeling Genetic Epileptic Encephalopathies using Brain Organoids

This study uses brain organoids to model WOREE, a severe epileptic encephalopathy, identifying CNS abnormalities and showing potential therapeutic rescue via WWOX expression.

Potassium channel regulators are differentially expressed in hippocampi of Ts65Dn and Tc1 Down syndrome mouse models

The paper measures differential expression of potassium channel genes in Down syndrome mouse models and identifies correlations between channel genes.