Author

Loukas Argyriou

Universitätsmedizin GöttingenORCID 0000-0002-9816-2109Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Signature Assays, Organisms & Methods

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Organism:human· 2 Research Focus:differential expression· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Assay:scRNA-seq· 1 Approach:statistical model· 1 Research Focus:variant calling· 1 Assay:whole-genome sequencing· 1

Frequent Co-Authors

Alexander WolffiD· 2 shared Arne ZibatiD· 2 shared Bernd WollnikiD· 2 shared Christian MülleriD· 2 shared Gökhan YigitiD· 2 shared Ipek Ilgin GönençiD· 2 shared Lukas CyganekiD· 2 shared Markus RäschleiD· 2 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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2 shared papersGenetics

Alexander WolffORCID

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2 papers

Recent·Most cited

BTRR complex deficiency is a driver for genomic instability in Bloom syndrome

Ipek Ilgin Gönenç, Alexander Wolff, Alexandra Viktoria Busley, Angela Wieland, Andréa E. Tijhuis, Christian Müller, René Wardenaar, Loukas Argyriou, Silke Kaulfuß, Markus Räschle, Diana C.J. Spierings, Floris Foijer, Holger Bastians, Andrew N. Blackford, Gökhan Yigit, , Bernd Wollnik

This study shows that BTRR complex deficiency increases genomic instability through copy number alterations, enriched at fragile sites, using CRISPR-edited iPSC models.

bioRxiv · Apr 17, 2025 · PreprintGenetics

Single-cell transcription profiles in Bloom syndrome patients link BLM deficiency with altered condensin complex expression signatures

Ipek Ilgin Gönenç, Alexander Wolff, Julia Schmidt, Arne Zibat, Christian Müller, Lukas Cyganek, Loukas Argyriou, Markus Räschle, Gökhan Yigit, Bernd Wollnik

This study uses single-cell transcriptome analysis to show that BLM deficiency in Bloom syndrome patients alters gene expression related to mitosis, genomic instability, and condensin complexes.

Human Molecular Genetics · Jan 24, 2022Peer-reviewedGenetics